Fibromyalgia, milnacipran and experimental pain modulation: study protocol for a double blind randomized controlled trial
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چکیده
منابع مشابه
Fibromyalgia, milnacipran and experimental pain modulation: study protocol for a double blind randomized controlled trial
BACKGROUND The prevalence of fibromyalgia increases worldwide and is characterized by widespread and chronic pain. Treatment is difficult and includes both drug and non-drug approaches. Milnacipran, an antidepressant, is used for fibromyalgia, with a possible beneficial effect on central pain modulation. Our hypothesis is that the efficacy of milnacipran in fibromyalgia depends on the performan...
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BACKGROUND Investigations based on quantitative sensory testing have consistently shown evidence of allodynia in fibromyalgia syndrome (FMS) patients involving both the spinal and supraspinal pain regulatory systems. Functional imaging studies have demonstrated enhanced neural activities in pain-related brain areas as well as impairment of pain inhibition in the descending nociceptive regulator...
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OBJECTIVE To evaluate the safety and efficacy of milnacipran, a dual norepinephrine and serotonin reuptake inhibitor, in the treatment of fibromyalgia (FM). METHODS A 27-week, randomized, double-blind, multicenter study compared milnacipran 100 and 200 mg/day with placebo in the treatment of 888 patients with FM. Two composite responder definitions were used to classify each patient's individ...
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ژورنال
عنوان ژورنال: Trials
سال: 2015
ISSN: 1745-6215
DOI: 10.1186/s13063-015-0659-4